Available data

Data released with the package.

multiome_congas_object

Multiome congas object

metadata

Dataframe containing cell type annotations for the 10x multiome lymphoma dataset.

atac_counts

Example tibbles with input ATAC data in the format for (R)CONGAS+

rna_counts

Example tibbles with input RNA data in the format for (R)CONGAS+

Main functions

Functions to create and fit a dataset.

create_congas_tibble()

Format the input counts before creating the CONGAS+ object

init()

Create a dataset.

auto_config_run()

Determine data-based hyperparameters for the Bayesian priors.

auto_normalisation_factor()

Compute empirical normalisation factors (library size)

segments_selector_congas()

Filter segments where the optimal number of clusters is 1.

fit_congas()

Fit an (R)CONGAS+ model

Getters

Functions to extract information from a model.

get_input()

Extract input data.

get_fit()

Extract fit data.

stat()

Compute the statistics of a dataset.

Filtering

Functions to pre-process inputs and post-process models.

filter_known_genes()

Filter genes from an RNA tibble.

filter_counts_by_quantile()

Filter observed counts by quantile.

filter_segments()

Filter segments.

filter_outliers()

Filter per-segment outliers by quantiles.

filter_missing_data()

Filter per-segment outliers by quantiles.

Plotting functions

Functions to plot data and fits.

plot_data()

Plot data.

plot_fit()

Plot fits.

S3 functions

The rcongasplus S3 object functions.

print.rcongasplus()

Print for an object of class 'rcongasplus'.

plot(<rcongasplus>)

Plot for an object of class 'rcongasplus'.

Downstream analyses

Functions to perform additional analyses downstream of the CONGAS+ inference.

build_clone_tree()

Build Clone Tree form a CONGAS+ object Using medicc2