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Introduction

Tissue simulation

Learn how to simulate tumour evolution

Tissue sampling

How to sample cells from a simulated tissue

Simulating Mutations

How to simulate mutations on sampled cells

Sequencing Simulation

How to simulate sample sequencing

Advanced techniques

Growth Models

What is a growth model and which growth models are implemented by rRACES

Formula-base simulation constraints

Simulate a tissue evolution until a simulation state formula does not hold

Customizing mutation engine

How to customize the mutation engine and its indices

Infinite Site Model

How to enable/disable the infinite site model

Partitioning samples (FACS)

How to partitioning samples, sorting cells, and simulate FACS

Time Series Analysis

Analyse the evolution of the system over time

Tests and Examples

A three-mutants sampling example

Sampling a three-mutants simulation

SCOUT

The Simulated Cohort of Universal Tumours (SCOUT)