De novo signatures refinement.

Function to refine the inferred de novo signatures. The function performs a linear combination between de novo and reference signatures. If a de novo signature can be explained as a linear combination of one or more reference signatures, it will be removed and its exposures will be distributed among the similar signatures.

Usage

refine_denovo_signatures(x, types = get_types(x))

Arguments

x

bascule object.

types

List of variant types to perform de novo refinement on.

Value

bascule object.